TLRs and innate immunity.

P-17: Expression of Cell Surface Toll-Like Receptors in the Human Male Reproductive Tract

Background: Male infertility refers to the inability of a male to achieve a pregnancy in a fertile female. The root of many causes of infertility is miscommunication between immune and reproductive system. Male reproductive system is very sensitive and vulnerable, infections can hinder maturation and movement of spermatozoa lead to impaired fertility.All species need an immediate reply to the m...

P-82: The Role of Toll-Like Receptor 2 in Ectopic Pregnancy

Background: The innate immune system is our first line of defense against invading pathogens. Toll–like receptors (TLRs) have been identified as a key role in mediating the function of innate immune system which bridges the gap between innate and adaptive immunity. For example, TLR2 is able to act as a homodimer to recognize lipoteichoic acids of Gram-positive bacteria but as a heterodimer with...

The Effect of Induced Hyperglycemia (Diabetes Type 1) on the mRNA Level of Toll-Like Receptor 4 Gene in the Diabetic Heart of Wistar Rats.

Abstract Objective: The previous studies indicated that the TLRs especially Toll-like receptor 4) TLR4 (are involved in the process of diabetes. The aim of the present research was to investigate the time course expression pattern of TLR4-a main component of innate immune system- in mRNA levels in the heart tissue of diabetic male wistar rats. Materials and Methods: In this research, adu...

The Role of Toll Like Receptors in Pregnancy

Neonatal innate immunity and Toll-like receptor

The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-type immune responses, and not Th2-type immune responses, which are enhanced. And the impaired re...

In silico Study of Toll-Like Receptor 4 Binding Site of FimH from Uropathogenic Escherichia coli

  Introduction : The innate immune system as the first line of defense against the pathogens recognizes pathogen-associated molecular patterns (PAMPs) by Toll-Like Receptors (TLRs). Interaction of bacterial PAMPs by TLRs results in activation of innate and acquired immunity. FimH adhesin, a minor component of type 1 fimbriae encoded by Uropathogenic Escherichia coli (UPEC) is a PAMP of TLR4 tha...